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Área de trabajo: Forense

Título: Screening en Análisis de Control de Doping en Equinos, con Ultra Alta Resolución y Masa Exacta.

Título original: Screening in Equine Doping Control Analysis with Ultrahigh Resolution and Accurate Mass.

Autor: Yves Moulard, Yves Bonnaire, Laboratoire des Courses Hippiques, Verrières-Le Buisson, France;

Bénédicte Duretz, Thermo Fisher Scientific, Les Ulis, France; Dennis Nagtalon, Thermo Fisher Scientific, San Jose, CA, USA

screening-en-analisis-de-control-de-doping-en-equinos-con-ultra-alta-resolucion-y-masa-exacta

Introduction: Triple quadrupole or tandem mass analyzers have been used most frequently in the accurate identification, confirmation, and quantitation of prohibited compounds in a single analysis. In addition, ion trap and quadrupole time-of-flight mass analyzers have been useful for screening and confirming results. However, these technologies cannot address the main requirements of equine doping control analysis such as:

• Data re-interrogation

• Analyze and monitor a vast number of compounds

• Fast and easy method development, instrument operation, and data interpretation

• Efficient separation of analytes from interferences present in the matrix

• Highly confident identification of compounds. Here we present a screening approach that uses ultrahigh resolution (R = 50,000) and accurate mass in positive and negative mode for the screening of illicit substances in urine matrix using the Thermo Scientific Exactive benchtop mass spectrometer. More than 120 analytes are screened using this method. Confirmation is made using the exact mass of the analytes in positive and negative mode (if available) and the retention time.

Goal

To demonstrate a new approach using ultrahigh resolution (> 50,000) and accurate mass for the screening of illicit substances in a urine matrix using the Exactive™ mass spectrometer, a new high performance benchtop LC/MS instrument equipped with Thermo Scientific Orbitrap technology, for doping control analysis.

 

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